Alpha 2 -Adrenergic Receptor–Induced Vascular Constriction in Blacks and Whites
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چکیده
منابع مشابه
Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites.
Black Americans have a reduced hypotensive response to the alpha2-adrenergic receptor agonist clonidine compared with whites, despite similar central sympathoinhibition. This reduced hypotensive response might be explained by greater postsynaptic vascular alpha2-adrenergic receptor vasoconstrictive response. However, clonidine has a low alpha2/alpha1 selectivity ratio. Therefore, to determine t...
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From time to time, the public is startled by a further report on the extreme commonness of dental caries. Such a report is that on adult dental health in Scot land.' Commenting on the information given, a leading article in L a n c e t entitled ‘Something rotten in Scotland and elsewhere’, noted that 44% of Scots over the age of 16 have lost all their natural teeth; oyer half go to the dentist...
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Blacks appear, on average, to retain more Na than whites. A higher production rate of mineralocorticoids could explain the greater Na retention in blacks. Although production of aldosterone has been shown to be lower in blacks, the level of another mineralocorticoid may be increased. Plasma levels of deoxycorticosterone and cortisol were measured in young whites (n=23; age=16.4+/-3.1[SD] years)...
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OBJECTIVE Abnormalities in nitric oxide (NO) bioavailability have been reported in blacks. Whether there are differences in endothelium-derived hyperpolarizing factor (EDHF) in addition to NO between blacks and whites and how these affect physiological vasodilation remain unknown. We hypothesized that the bioavailability of vascular NO and EDHF, at rest and with pharmacological and physiologica...
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BACKGROUND Although adrenergic activation plays a major role in the initiation of experimental myocardial ischemia, the significance of alpha-adrenergic coronary constriction in humans has been questioned. The present study assessed the impact of selective alpha-adrenergic receptor activation in patients with normal or atherosclerotic coronary arteries. METHODS AND RESULTS In 39 patients, cor...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2004
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000103694.30164.c7